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Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells
 
Creator Chaudhary, Surbhi
Patidar, Anil
Dhiman, Asmita
Chaubey, Gaurav Kumar
Dilawari, Rahul
Talukdar, Sharmila
Modanwal, Radheshyam
Raje, Manoj
 
Subject QR Microbiology
 
Description Rapid clearance of apoptotic cells by phagocytes is crucial for organogenesis, tissue homeostasis, and resolution of inflammation. This process is initiated by surface exposure of various ‘eat me’ ligands. Though phosphatidylserine (PS) is the best recognized general recognition ligand till date, recent studies have shown that PS by itself is not sufficient for clearance of apoptotic cells. In this study, we have identified a specific pleioform of GAPDH (Glyceraldehyde 3-phosphate dehydrogenase) that functions as an ‘eat me’ signal on apoptotic cell surface. This specific form of GAPDH which is exposed on surface of apoptotic cells was found to interact with CD14 present on plasma membrane of phagocytes leading to their engulfment. This is the first study demonstrating the novel interaction between multifunctional GAPDH and the phagocytic receptor CD14 resulting in apoptotic cell clearance (efferocytosis).
 
Publisher Nature Publishing Group
 
Date 2021-09-30
 
Type Article
PeerReviewed
 
Relation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482365/
http://crdd.osdd.net/open/2707/
 
Identifier Chaudhary, Surbhi and Patidar, Anil and Dhiman, Asmita and Chaubey, Gaurav Kumar and Dilawari, Rahul and Talukdar, Sharmila and Modanwal, Radheshyam and Raje, Manoj (2021) Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells. CELL DEATH & DISEASE, 12 (10).