Record Details

Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) modulates protein aggregation

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) modulates protein aggregation
 
Creator Chaudhary, Surbhi
Dhiman, Asmita
Patidar, Anil
Malhotra, Himanshu
Talukdar, Sharmila
Dilawari, Rahul
Chaubey, Gaurav Kumar
Modanwal, Radheshyam
Raje, Chaaya Iyengar
Raje, Manoj
 
Subject QR Microbiology
 
Description Onset of protein aggregation reflects failure of the cellular folding machinery to keep aggregation-prone protein from misfolding and accumulating into a non-degradable state. FRET based analysis and biochemical data reveal that cytosolic prion (cyPrP) and httQ-103 interact with the multifunctional protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) leading to few detectable aggregates in GAPDH-over expressing cells.The preventive effect of GAPDH suggests that this abundant and long-lived cytoplasmic protein has an active role in the shielding and maintenance, in soluble form of proteins as heterogeneous as huntingtin and cyPrP.
 
Publisher Elsevier
 
Date 2021-10-01
 
Type Article
PeerReviewed
 
Relation https://www.sciencedirect.com/science/article/abs/pii/S0925443921001356
http://crdd.osdd.net/open/2751/
 
Identifier Chaudhary, Surbhi and Dhiman, Asmita and Patidar, Anil and Malhotra, Himanshu and Talukdar, Sharmila and Dilawari, Rahul and Chaubey, Gaurav Kumar and Modanwal, Radheshyam and Raje, Chaaya Iyengar and Raje, Manoj (2021) Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) modulates protein aggregation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867 (10).