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Improvisation and Evaluation of Laterosporulin Coated Titanium Surfaces for dental Applications: An In Vitro Investigation

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Improvisation and Evaluation of Laterosporulin Coated Titanium Surfaces for dental Applications: An In Vitro Investigation
 
Creator Grover, Vishakha
Chopra, Priyanka
Mehta, Manjula
Kumari, Sumeeta
Sehgal, Komal
Jain, Rajni
Lal, Rup
Korpole, Suresh
 
Subject QR Microbiology
 
Description Despite recent improvement in implant survival rates, there remains a significant demand for enhancing the long-term clinical efficacy of titanium (Ti) implants, particularly for the prevention of peri-implantitis. Bioactive substances such as antimicrobial peptides are emerging as effective alternatives for contemporary antimicrobial agents used in dental health care. Current research work was focused to use laterosporulins that are non-haemolytic cationic antimicrobial peptides from Brevibacillus spp. for coating commercially available Ti discs. The coated Ti surfaces were evaluated in vitro for biofilm formation by two dental plaque isolates Streptococcus gordonii strain DIGK25 and S. mutans strain DIGK119 as representatives of commensal and pathogenic streptococci respectively. The biofilm inhibition was ascertained with replicated experiments on hydroxyapatite discs and confirmed by florescence microscopy. The laterosporulin coated Ti discs showed significantly reduced biofilm formation by oral streptococci and displayed promising potential to enhance the antibacterial surface properties. Such improvised Ti surfaces may curb the menace of oral streptococcal biofilm formation on dental implants and the associated implant failures.
 
Publisher EUROPE PMC
 
Date 2021-04-01
 
Type Article
PeerReviewed
 
Relation https://europepmc.org/article/med/33927461
http://crdd.osdd.net/open/2769/
 
Identifier Grover, Vishakha and Chopra, Priyanka and Mehta, Manjula and Kumari, Sumeeta and Sehgal, Komal and Jain, Rajni and Lal, Rup and Korpole, Suresh (2021) Improvisation and Evaluation of Laterosporulin Coated Titanium Surfaces for dental Applications: An In Vitro Investigation. INDIAN JOURNAL OF MICROBIOLOGY, 61 (2). pp. 203-211.