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Anti-inflammatory and analgesic activities of imidazolyl triazolo hydroxamic acid derivatives

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Field Value
 
Title Anti-inflammatory and analgesic activities of imidazolyl triazolo hydroxamic acid derivatives
 
Creator Pal, Dilip Kumar
Saha, Supriyo
Kumar, Sushil
 
Subject Antitumor
Carrageenan
Chemotherapy
Diclofenac Hydroxamic acid
Inflammation
Pain
 
Description 280-285
Hydroxamic acids are directly related with cancer and its progression. Long term exposure with inflammatory responses, dysplasia develops which leads to cancer. Metastasis of cancer and expression of transient potential receptor ankyrin-1 are known to cause severe pain. Here, we explored the possibility of developing newer hydroxamic acid derivatives as anti-inflammatory and analgesic agent. Animals were administered with 100 mg/kg dose of the synthesized imidazolyl triazolo hydroxamic acid derivatives (FP1-FP12) and 50 mg/kg dose of standard diclofenac sodium. Carrageenan induced rat paw edema and Eddy’s hot plate methods were considered for anti-inflammatory and analgesic activities. Among all the synthesized molecules, FP10 and FP4 were the most effective anti-inflammatory and analgesic agent, respectively. The activity profile of remaining molecules as anti-inflammatory agents was as follows: FP4>FP9> FP8> FP2 and as analgesic activity profile was FP10>FP3>FP8 >FP11 >FP2 > FP12. Presence of ethyl- benzyl and furan groups in linker portion of the structure minimized both the anti-inflammatory and analgesic activities. Results have shown that compounds with electron releasing groups considerably enhance both anti-inflammatory and analgesic activities.
 
Date 2022-03-31T09:07:07Z
2022-03-31T09:07:07Z
2022-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/59411
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(04) [April 2022]