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Bone impairment in adolescent female rats chronically exposed to ethanol

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Title Bone impairment in adolescent female rats chronically exposed to ethanol
 
Creator Ferreira, Railson Oliveira
Fernandes, Rafael Monteiro
Bittencourt, Leonardo Oliveira
Alvarenga, María Olimpia Paz
Cartágenes, Sabrina Carvalho
Fernandes, Luanna Melo Pereira
Maia, Cristiane Socorro Ferraz
Lima, Rafael Rodrigues
 
Subject Femur
Scanning Electron Microscopy
 
Description 258-262
Ethanol consumption has increased among teenagers worldwide considerably,including females. Long-term ethanol
consumption in women has been reported to cause bone metabolism imbalance. However, only few studies are available on
the impact of long-term ethanol consumptionon bone morphology during adolescence. Here, we report the effects of chronic
ethanol consumption on bone structure in adolescent female rats. Twenty female Wistar rats (35 days old) received, by
gavage, distilled water (control) or ethanol (6.5 g/kg/day, 22.5% w/v) once daily for 55 days. After ethanol administration,
animals were perfused, and the femora were collected. Morphometric evaluations were performed by electron microscopy
scanning. Femora length, cortical bone thickness and medullar bone diameter was measured. The results demonstrated that
ethanol exposure during adolescence reduced the length of femurs, with a decrease of the anterior thickness, posterior
thickness, and mid-lateral diameter (P
 
Date 2022-03-31T09:55:02Z
2022-03-31T09:55:02Z
2022-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/59414
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(04) [April 2022]