Conjugation of enrofloxacin with amine functionalized zinc oxide nanoparticle enhances antibacterial activity in vitro
NOPR - NISCAIR Online Periodicals Repository
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Title |
Conjugation of enrofloxacin with amine functionalized zinc oxide nanoparticle enhances antibacterial activity in vitro
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Creator |
Mulla, Hussain Basha
K, Bharavi Jahan, Afroz M, Alpha Raj GS, Rao |
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Subject |
Antibiotic resistance
Antimicrobial efficacy Livestock Nanomaterials Multidrug resistance Poultry |
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Description |
233-240
Increased resistance to a large number of antibacterial drugs poses a serious challenge in chemotheraphy of infectious diseases. Here, we have made and attempt to redesign the existing chemotherapeutic agent enrofloxacin (EN) to treat resistant bacteria. Precisely, we synthezied EN conjugated zinc oxide nanoparticles (EN-ZNP) and explored enhancing the antibacterial activity of enrofloxacin. Zinc oxide nanoparticles (ZNP) were synthesized by microwave irradiation and amine functionalization by co-condensation with APTES and then by utilizing EPC/NHS chemistry, enrofoxacin was conjugated. Conjugation and their stability were confirmed by FT-IR spectra and Zeta potential. EN fraction in EN-ZNP was determined indirectly using UV-Vis spectroscopy. The MIC values obtained for EN-ZNP against MTCC cultures and clinical isolates of Escherichia coli, Salmonella typhimurium, Staphylococcus aureus were significantly (P |
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Date |
2022-03-31T10:01:33Z
2022-03-31T10:01:33Z 2022-04 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/59417 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.60(04) [April 2022]
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