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Conjugation of enrofloxacin with amine functionalized zinc oxide nanoparticle enhances antibacterial activity in vitro

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Title Conjugation of enrofloxacin with amine functionalized zinc oxide nanoparticle enhances antibacterial activity in vitro
 
Creator Mulla, Hussain Basha
K, Bharavi
Jahan, Afroz
M, Alpha Raj
GS, Rao
 
Subject Antibiotic resistance
Antimicrobial efficacy
Livestock
Nanomaterials
Multidrug resistance
Poultry
 
Description 233-240
Increased resistance to a large number of antibacterial drugs poses a serious challenge in chemotheraphy of infectious
diseases. Here, we have made and attempt to redesign the existing chemotherapeutic agent enrofloxacin (EN) to treat
resistant bacteria. Precisely, we synthezied EN conjugated zinc oxide nanoparticles (EN-ZNP) and explored enhancing the
antibacterial activity of enrofloxacin. Zinc oxide nanoparticles (ZNP) were synthesized by microwave irradiation and amine
functionalization by co-condensation with APTES and then by utilizing EPC/NHS chemistry, enrofoxacin was conjugated.
Conjugation and their stability were confirmed by FT-IR spectra and Zeta potential. EN fraction in EN-ZNP was determined
indirectly using UV-Vis spectroscopy. The MIC values obtained for EN-ZNP against MTCC cultures and clinical isolates of
Escherichia coli, Salmonella typhimurium, Staphylococcus aureus were significantly (P
 
Date 2022-03-31T10:01:33Z
2022-03-31T10:01:33Z
2022-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/59417
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(04) [April 2022]