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Anti-inflammatory and analgesic activities of imidazolyl triazolo hydroxamic acid derivatives

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Title Statement Anti-inflammatory and analgesic activities of imidazolyl triazolo hydroxamic acid derivatives
 
Added Entry - Uncontrolled Name Pal, Dilip Kumar; Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, Chhattisgarh - 495 009, India
Saha, Supriyo
Kumar, Sushil
 
Uncontrolled Index Term Antitumor; Carrageenan; Chemotherapy; Diclofenac Hydroxamic acid; Inflammation; Pain
 
Summary, etc. Hydroxamic acids are directly related with cancer and its progression. Long term exposure with inflammatory responses, dysplasia develops which leads to cancer. Metastasis of cancer and expression of transient potential receptor ankyrin-1 are known to cause severe pain. Here, we explored the possibility of developing newer hydroxamic acid derivatives as anti-inflammatory and analgesic agent. Animals were administered with 100 mg/kg dose of the synthesized imidazolyl triazolo hydroxamic acid derivatives (FP1-FP12) and 50 mg/kg dose of standard diclofenac sodium. Carrageenan induced rat paw edema and Eddy’s hot plate methods were considered for anti-inflammatory and analgesic activities. Among all the synthesized molecules, FP10 and FP4 were the most effective anti-inflammatory and analgesic agent, respectively. The activity profile of remaining molecules as anti-inflammatory agents was as follows: FP4>FP9> FP8> FP2 and as analgesic activity profile was FP10>FP3>FP8 >FP11 >FP2 > FP12. Presence of ethyl- benzyl and furan groups in linker portion of the structure minimized both the anti-inflammatory and analgesic activities. Results have shown that compounds with electron releasing groups considerably enhance both anti-inflammatory and analgesic activities.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-04-01 11:57:42
 
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http://op.niscair.res.in/index.php/IJEB/article/view/61923
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 04 (2022): IJEB [APRIL 2022]
 
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