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Antibiotic resistance and enzymatic degradation of beta lactam antibiotics

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Title Antibiotic resistance and enzymatic degradation of beta lactam antibiotics
 
Creator almaaz, moghal
 
Subject Beta lactam antibiotic, Beta lactamase, enzymatic degradation, infection
 
Description Beta-lactam antibiotic, a broad antibacterial spectrum which consist of beta-lactam ring in its structure, includes penicillin, carbapenems, cephalosporins, cephamycins and monobactams. Due to its high efficiency and therapeutic value these antibiotics are widely administered as either by oral or parenteral. These antibiotics acts upon the bacteria and cause cell death by binding to PBP (penicillin binding proteins) and thereby inhibiting the synthesis of the bacterial cell wall. Beta-lactamases, an enzyme produced mostly by gram negative bacteria to overcome the antibiotics by hydrolyzing the amide bond of the β-lactam ring. These enzymes are coded by the genes found in bacterial chromosome and also as plasmids and transposons. These β-lactamases are further divided based on the two classifications, first classification is based on amino acid sequence similarities and second is based on the functionality. As the usage of antibiotic is getting higher nowadays, for the treatment of broad range of bacterial infections which in turn makes the bacteria to develop resistance by mechanisms like, prevention of drug-target interaction, antibiotic efflux from the cell, and direct destruction or alteration of the molecule. These review focus on the different classes of β-lactamases and its various aspects involved in the chemical and enzymatic degradation
 
Date 2022-04-05T13:18:57Z
2022-04-05T13:18:57Z
2022
 
Type Article
 
Identifier 2582-6492 (Online); 0036-8512 (Print)
http://nopr.niscair.res.in/handle/123456789/59441
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source SR Vol.59(04) [April 2022]