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Evaluation of pharmacological and catalytic activity of CuO and Zn doped CuO nanoparticles

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Title Evaluation of pharmacological and catalytic activity of CuO and Zn doped CuO nanoparticles
 
Creator Saranya, R
Ali, M Mubarak
Jeyalakshmi, K
 
Subject CuO
Zn-CuO NPs
Antibacterial
Antioxidant
Cytotoxicity
MCF7
A549
 
Description 124-129
CuO and Zn doped CuO nanoparticles (Zn-CuO NPs) with varying concentration i.e., ZnxCu1−xO (where x = 0, 0.5, 1, and
1.5%) have been prepared via microwave assisted method. The spheroid structure of CuO NPs and the nanorod structure of Zn-
CuO NPs have been determined using High Resolution Scanning Electron Microscopy (HR-SEM) analysis. Elemental analysis
has been carried out using Energy Dispersive X-ray Analysis (EDAX). The particle size and surface area of CuO and Zn-CuO
NPs have been confirmed by Brunauer–Emmett–Teller (BET) method. The antibacterial studies have been revealed that
Zn(1.5%)-CuO NPs exhibited maximum zone of inhibition (19-29 mm) against the tested four bacterial strains. Zn-CuO NPs have
been displayed robust action of antibacterial activity with minimum inhibitory concentration (MIC) of 0.09 μM against
Campylobacter coli (C. Coli). DPPH and H2O2 radical scavenging assay investigation have been revealed that the significant
scavenging activity has showed by Zn(1.5%)-CuO. The in vitro cytotoxicity evaluation of synthesized material against human
breast (MCF7) and human lung (A549) cancer cell lines have been demonstrated that Zn(1.5%)-CuO NPs exhibited better
cytotoxic activity against MCF7 cell lines (97.5% cell death) than A549 cell lines (90% cell death).
 
Date 2022-04-06T09:20:44Z
2022-04-06T09:20:44Z
2022-02
 
Type Article
 
Identifier 0975-1017 (Online); 0971-4588 (Print)
http://nopr.niscair.res.in/handle/123456789/59463
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEMS Vol.29(1) [February 2022]