Record Details

<p style="text-align: justify;">Design and synthesis of novel <em>s</em>-triazine based coumarin, quinoline, morpholine and isoniazid derivatives and their antitubercular and antimicrobial evaluation</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Design and synthesis of novel <em>s</em>-triazine based coumarin, quinoline, morpholine and isoniazid derivatives and their antitubercular and antimicrobial evaluation</p>
 
Added Entry - Uncontrolled Name Mahyavanshi, Jyotindra ; Department of Chemistry, Sankalchand Patel University,Visnagar 384 315, India
Shrivastava, Vijay ; Department of Chemistry, Sankalchand Patel University,Visnagar 384 315, India
Patel, Shraddha ; Department of Chemistry, Sankalchand Patel University,Visnagar 384 315, India
Pandya, Jayesh ; Department of Chemistry, Sankalchand Patel University,Visnagar 384 315, India
 
Uncontrolled Index Term s-Triazine, antimycobacterial activity, coumarin, quinoline, isoniazide, morpholine
 
Summary, etc. <p class="Abstract" style="text-align: justify;">This study presents the synthesis of novel <em>s</em>-triazine derivatives. The synthetic route to final <em>s</em>-triazines consists of two nucleophilic substitution reactions of 4-hydroxy benzonitrile and 8-hydroxyquinoline or 8-hydroxy-7-methyl coumarin or isoniazid or morpholine with 2,4,6-trichloro-1,3,5-triazine resulting in 2,4-disubstituted-6-chloro-1,3,5-triazine derivatives to introduce the various amines functionality. The structures of the compounds have been elucidated with the aid of IR, <sup>1</sup>H and <sup>13</sup>C NMR, mass spectroscopy and elemental analysis. The title compounds have then been investigated for their <em>in vitro</em> antimycobacterial activity against <em>Mycobacterium tuberculosis</em> H37Rv strain by using BACTEC MGIT and Lowenstein-Jensen MIC method and antimicrobial evaluation.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-03-24 15:14:48
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/61718
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 3 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en