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<p style="text-align: justify;">Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents</p>

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Title Statement <p style="text-align: justify;">Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents</p>
 
Added Entry - Uncontrolled Name Jain, Surabhi ; Faculty of Pharmacy, B. Pharmacy College Rampura-Kakanpur (Gujarat Technological University), Godhra 388 713, India
Sen, Dhrubo Jyoti; School of Pharmacy, Techno India University, Sector-V, EM-4, Salt Lake Campus, Kolkata 700 091, India
 
Uncontrolled Index Term Tuberculosis, imidazopyridine, ATP synthase, Lipinski rule of 5, ADME-T
 
Summary, etc. <p style="text-align: justify;">Tuberculosis is a global threat that is in urgent need for new molecules. In the same perspective, Imidazopyridine derivatives have been synthesized against target ATP synthase. It is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. Bedaquiline that primarily targets ATP now is most effective in treatment of tuberculosis. All synthesized molecules pass Lipinski rule of 5 and are non-substrate of CYP450 enzymes. They didn’t portray significant anti-tubercular activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-03-24 15:14:48
 
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http://op.niscair.res.in/index.php/IJC/article/view/61721
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 3 (2022): Indian Journal of Chemistry-(IJC)
 
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