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<p>Synthesis, characterization and evaluation of thiopyrimidine derivatives as possible antimicrobial agents</p>

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Title Statement <p>Synthesis, characterization and evaluation of thiopyrimidine derivatives as possible antimicrobial agents</p>
 
Added Entry - Uncontrolled Name Kumar, J Bharath ; Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy Ramnagar, Hanamkonda 506 001, India Pathfinder Institute of Pharmacy Education and Research, Mamnoor, Warangal 506 166, India
Rajyalaxmi, I ; Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy Ramnagar, Hanamkonda 506 001, India MLR Institute of Pharmacy, Dundigal, Quthbullapur, Hyderabad 500 043, India
Venkateshwarlu, K ; Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy Ramnagar, Hanamkonda 506 001, India
Sirisha, K ; Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy Ramnagar, Hanamkonda 506 001, India
 
Uncontrolled Index Term Chalcone, thiopyrimidine, S-alkylation, molecular properties, anti-microbial
 
Summary, etc. <p style="text-align: justify;">A series of new thiopyrimidine derivatives have been synthesized <em>via</em> the reaction of Chalcones <strong>3a-c</strong> with thiourea to give the corresponding pyrimidine thiones <strong>4a-c</strong>. S-alkylation of pyrimidine thiones have resulted in novel 4,6-diaryl-2-alkyl thiopyrimidine <strong>5a-i </strong>derivatives. Molecular properties like number of hydrogen bond acceptors, number of hydrogen bond donors, volume, polar surface area, molar refractivity, number of rotatable bonds and drug likeness for synthesized compounds have been predicted by using different softwares such as Molinspiration, Molsoft and Chemsketch. The newly synthesized 4,6-diaryl-2-alkyl thiopyrimidine derivatives <strong>5a-i</strong> have been evaluated for their possible anti-microbial activity. Compounds <strong>5b</strong>, <strong>5d</strong> and <strong>5e</strong> have revealed significant activity against <em>E. coli</em>,<em> P. aerugenosa </em>(Gram +ve) and <em>B. subtilis</em>, <em>S. aureus</em> (Gram −ve) species while compounds <strong>5a</strong>, <strong>5c</strong>, <strong>5f</strong><strong>-i</strong> are moderately active as compared to the standard drug Ciprofloxacin. Compounds <strong>5c</strong> and <strong>5g</strong> show potent anti-fungal activity against <em>Penicillium </em>species amongst the series in comparison to the standard Fluconazole.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-03-24 15:14:48
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/61719
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 3 (2022): Indian Journal of Chemistry-(IJC)
 
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