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<p style="text-align: justify;">A green method for the synthesis of isoxazolyl aryl thieno[2,3-<em>d</em>]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity</p>

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Title Statement <p style="text-align: justify;">A green method for the synthesis of isoxazolyl aryl thieno[2,3-<em>d</em>]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity</p>
 
Added Entry - Uncontrolled Name Saini, Ramakrishna ; Department of Chemistry, Kakatiya University, Warangal 506 009, India
Malladi, Srinivas Reddy; Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, Thimmapur, Karimnagar 505 481, India
Dharavath, Nagaraju ; Department of Chemistry, Telangana University, Nizamabad 503 322, India
 
Uncontrolled Index Term Green synthesis, polyethylene glycol (PEG), isoxazolylarylthieno[2,3-d]pyrimidinones, antimicrobial activity
 
Summary, etc. <p style="text-align: justify;">Novel series of isoxazolyl aryl thieno[2,3-<em>d</em>]pyrimidinones <strong>4</strong> have been synthesized from (<em>E</em>)-2-amino-5-(3-methyl-4-nitroisoxazol-5-yl)-<em>N</em>-(3-methyl-5-styrylisoxazol-4-yl)-4-arylthiophene-3-carboxamide synthon <strong>3</strong>. Compound <strong>3</strong> is obtained by reaction of 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-aryl-ethanone <strong>1</strong>, <em>N</em><sub>1</sub>-{3-methyl-5-[(<em>E</em>)-2-aryl-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide <strong>2</strong> and elemental sulfur in PEG-400. Isoxazolyl aryl thieno[2,3-<em>d</em>]pyrimidinones <strong>4</strong> have been obtained from compounds <strong>3</strong> by tandem <em>N</em>-acetylation and cyclodehydration with acetic anhydride. Compounds <strong>3a-q</strong> and <strong>4a-q</strong> have been characterized by IR, <sup>1</sup>H and <sup>13</sup>C NMR, and mass spectral data. The title compounds <strong>4a-q</strong> have been evaluated for their antimicrobial activity. Compounds <strong>4b</strong>, <strong>4c</strong>, <strong>4d</strong>, <strong>4e</strong>, <strong>4j</strong>, <strong>4k</strong>, <strong>4l</strong> and <strong>4m</strong> exhibit significant antimicrobial activity, compared to that of standard drugs.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-03-24 15:14:48
 
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http://op.niscair.res.in/index.php/IJC/article/view/61733
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 3 (2022): Indian Journal of Chemistry-(IJC)
 
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