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Immunotherapeutic Role of NOD-2 and TLR-4 Signaling as an Adjunct to Antituberculosis Chemotherapy

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Immunotherapeutic Role of NOD-2 and TLR-4 Signaling as an Adjunct to Antituberculosis Chemotherapy
 
Creator Mohammad, Aqdas
Maurya, Sudeep K
Pahari, Susanta
Singh, Sanpreet
Khan, Nargis
Sethi, Kanupriya
Kaur, Gurpreet
Agrewala, J N
 
Subject QR Microbiology
 
Description Tuberculosis (TB) treatment is lengthy and inflicted with severe side-effects. Here, we attempted a novel strategy to reinforce host immunity through NOD-like receptor (NOD-2) and Toll-like receptor (TLR-4) signaling in the murine model of TB. Intriguingly, we noticed that it not only bolstered the immunity but also reduced the dose and duration of rifampicin and isoniazid therapy. Further, we observed expansion in the pool of effector (CD44hi, CD62Llo, CD127hi) and central (CD44hi, CD62Lhi, CD127hi) memory CD4 T cells and CD8 T cells and increased the intracellular killing of Mycobacterium tuberculosis (Mtb) by activated dendritic cells [CD86hi, CD40hi, IL-6hi, IL-12hi, TNF-αhi, nitric oxide (NO)hi] with significant reduction in Mtb load in the lungs and spleen of infected animals. We infer that the signaling through NOD-2 and TLR-4 may be an important approach to reduce the dose and duration of the drugs to treat TB.
 
Publisher Washington, D.C. : American Chemical Society
 
Date 2021-11-12
 
Type Article
PeerReviewed
 
Relation https://pubs.acs.org/doi/10.1021/acsinfecdis.1c00136
http://crdd.osdd.net/open/2944/
 
Identifier Mohammad, Aqdas and Maurya, Sudeep K and Pahari, Susanta and Singh, Sanpreet and Khan, Nargis and Sethi, Kanupriya and Kaur, Gurpreet and Agrewala, J N (2021) Immunotherapeutic Role of NOD-2 and TLR-4 Signaling as an Adjunct to Antituberculosis Chemotherapy. ACS applied materials & interfaces. pp. 2999-3008. ISSN 1944-8252