Docking, synthesis and evaluation of N-(2-(4-methoxy-2-oxo-1-phenyl/methyl- 1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents
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Title |
Docking, synthesis and evaluation of N-(2-(4-methoxy-2-oxo-1-phenyl/methyl- 1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents
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Creator |
Gaonkar, Sahili Ganesh
Phadte, Soniya Desai, Shivlingrao Mamle Biradar, Bheemanagouda Porab, Nikita |
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Subject |
Quinolin-2-one
sulphonamides molecular docking antidiabetic activity glucose oxidase-peroxidase |
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Description |
431-437
The current research work involves in silico docking studies, synthesis, characterisation and study on hypoglycemicactivity of a series of N-(2-(4-methoxy-1-methyl/phenyl-2-oxo-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-Nsubstitutedprimaryamino) -benzenesulfononamides [IVa/b (1-6)]. Compounds exhibit prominent anti-diabetic activity by glucose oxidase peroxidase (GOD-POD) method which involves measurement of average serum glucose levels in mg/dl as well as conserved hydrogen bonds with one or more amino acid residues in the active pocket of murine 11β-hydroxysteroid dehydrogenase domain. Among all the synthesized compounds, compound IVb2 shows prominent anti-diabetic activity and higher Moldock score as compared to standard drug Glibenclamide. Structural analysis of the synthesized compounds has been done by standard spectroscopic techniques. |
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Date |
2022-04-19T06:21:36Z
2022-04-19T06:21:36Z 2022-04 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59540 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.61(04) [April 2022]
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