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Docking, synthesis and evaluation of N-(2-(4-methoxy-2-oxo-1-phenyl/methyl- 1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents

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Title Docking, synthesis and evaluation of N-(2-(4-methoxy-2-oxo-1-phenyl/methyl- 1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents
 
Creator Gaonkar, Sahili Ganesh
Phadte, Soniya
Desai, Shivlingrao Mamle
Biradar, Bheemanagouda
Porab, Nikita
 
Subject Quinolin-2-one
sulphonamides
molecular docking
antidiabetic activity
glucose oxidase-peroxidase
 
Description 431-437
The current research work involves in silico docking studies, synthesis, characterisation and study on
hypoglycemicactivity of a series of N-(2-(4-methoxy-1-methyl/phenyl-2-oxo-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-Nsubstitutedprimaryamino)
-benzenesulfononamides [IVa/b (1-6)]. Compounds exhibit prominent anti-diabetic activity by
glucose oxidase peroxidase (GOD-POD) method which involves measurement of average serum glucose levels in mg/dl as
well as conserved hydrogen bonds with one or more amino acid residues in the active pocket of murine 11β-hydroxysteroid
dehydrogenase domain. Among all the synthesized compounds, compound IVb2 shows prominent anti-diabetic activity and
higher Moldock score as compared to standard drug Glibenclamide. Structural analysis of the synthesized compounds has
been done by standard spectroscopic techniques.
 
Date 2022-04-19T06:21:36Z
2022-04-19T06:21:36Z
2022-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59540
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(04) [April 2022]