Record Details

Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones

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Field Value
 
Title Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones
 
Creator Umarani, W A
Sony, K P
Hymavathi, K V
Kumar, M Murali Krishna
 
Subject Stetter reaction
1,4-diketones
antitubercular activity
MABA assay
docking
 
Description 411-415
Anti-tubercular activity (MIC 50μg/mL against Mtb H37Rv) have been reported in hispolons, which possess α,
β-unsaturated-1,3-diketone functional group. In the pursuit to optimize structure and bioactivity, various substituted
arylpentane-1,4-diones S1-8 have been synthesised. Upon screening, the test compounds show negligible antimicrobial
activity against the tested organisms at 100 μg/mL but show antitubercular activity against Mycobacterium tuberculosis
H37Rv strain with an MIC 0.8 to 25μg/mL. Compounds having a halogen at the ortho position on the aromatic ring show
highest potency (MIC 0.8μg/mL), implying a relation between the position of the halogen atom and anti-tubercular activity.
 
Date 2022-04-19T06:30:58Z
2022-04-19T06:30:58Z
2022-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59543
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(04) [April 2022]