Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones
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Title |
Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones
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Creator |
Umarani, W A
Sony, K P Hymavathi, K V Kumar, M Murali Krishna |
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Subject |
Stetter reaction
1,4-diketones antitubercular activity MABA assay docking |
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Description |
411-415
Anti-tubercular activity (MIC 50μg/mL against Mtb H37Rv) have been reported in hispolons, which possess α, β-unsaturated-1,3-diketone functional group. In the pursuit to optimize structure and bioactivity, various substituted arylpentane-1,4-diones S1-8 have been synthesised. Upon screening, the test compounds show negligible antimicrobial activity against the tested organisms at 100 μg/mL but show antitubercular activity against Mycobacterium tuberculosis H37Rv strain with an MIC 0.8 to 25μg/mL. Compounds having a halogen at the ortho position on the aromatic ring show highest potency (MIC 0.8μg/mL), implying a relation between the position of the halogen atom and anti-tubercular activity. |
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Date |
2022-04-19T06:30:58Z
2022-04-19T06:30:58Z 2022-04 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59543 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.61(04) [April 2022]
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