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Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds

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Field Value
 
Title Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds
 
Creator Ramya, S
Anusha, K
Tiwari, A K
Raju, B China
 
Subject Pyrazolines
pyrazoles
free-radical scavenging
α-glucosidase inhibitory activity
 
Description 399-404
A total of fifty pyrazolines 3a-y and pyrazoles 4a-y have been evaluated for their free-radical scavenging and
α-glucosidase inhibitory activities. The pyrazolines 3e, 3h, 3p, 3s and pyrazole 4e have been identified as potent ABTS.+
free-radical scavengers. The thiophene substituted pyrazoline 3s has shown potent ABTS.+ free radical scavenging activity
compared to thiophene substituted pyrazole 4s. Furanyl (4r), pyrazolyl (4t), 2-chloropyridinyl (4u-w), 2-chloroquinolinyl
(4x) and 4-chlorocoumarin (4y) pyrazoles have displayed moderate ABTS.+ free-radical scavenging activity. Pyrazoline 3i
and pyrazole 4b have shown moderate DPPH free-radical scavenging activity.
 
Date 2022-04-19T06:36:25Z
2022-04-19T06:36:25Z
2022-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59545
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(04) [April 2022]