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Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions
 
Creator Singh, Mona
Thakur, Mony
Mishra, Manish
Vibhuti, Rajkamal
Menon, A.M
Nagda, Girima
Dwivedi, V
Dakal, T.C
Yadav, Vinod
 
Subject QR Microbiology
 
Description Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecules which is responsible for several immune functions like T cell activation, extravasation, inflammation, etc. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators like cellular stress, proinflammatory cytokines, viral infection. These stimuli modulate the expression of ICAM-1 primarily through regulating the ICAM-1 gene transcription. On account of the presence of various binding sites for NF-κB, AP-1, SP-1, and many other transcription factors, the architecture of the ICAM-1 promoter become complex. Transcription factors in union with other transcription factors, coactivators, and suppressors promote their assembly in a stereospecific manner on ICAM-1 promoter which mediates ICAM-1 regulation in response to different stimuli. Along with transcriptional regulation, epigenetic modifications also play a pivotal role in controlling ICAM-1 expression on different cell types. In this review, we summarize the regulation of ICAM-1 expression both at the transcriptional as well as post-transcriptional level with an emphasis on transcription factors and signaling pathways involved.
 
Publisher Elsevier Science
 
Date 2021-12
 
Type Article
PeerReviewed
 
Relation https://www.sciencedirect.com/science/article/abs/pii/S0165247821001681?via%3Dihub
http://crdd.osdd.net/open/2958/
 
Identifier Singh, Mona and Thakur, Mony and Mishra, Manish and Vibhuti, Rajkamal and Menon, A.M and Nagda, Girima and Dwivedi, V and Dakal, T.C and Yadav, Vinod (2021) Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions. Immunology letters, 240. pp. 123-136. ISSN 0165-2478