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<p>Docking, synthesis and evaluation of <em>N</em>-(2-(4-methoxy-2-oxo-1-phenyl/methyl-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-<em>N</em>-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents</p>

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Title Statement <p>Docking, synthesis and evaluation of <em>N</em>-(2-(4-methoxy-2-oxo-1-phenyl/methyl-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-<em>N</em>-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents</p>
 
Added Entry - Uncontrolled Name Gaonkar, Sahili Ganesh; Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa 403 401, India
Phadte, Soniya ; Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa 403 401, India
Desai, Shivlingrao Mamle; Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa 403 401, India
Biradar, Bheemanagouda ; Department of Pharmacology, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa 403 401, India
Porab, Nikita ; Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa 403 401, India
 
Uncontrolled Index Term Quinolin-2-one, sulphonamides, molecular docking, antidiabetic activity, glucose oxidase-peroxidase
 
Summary, etc. <p style="text-align: justify;">The current research work involves <em>in silico</em> docking studies, synthesis, characterisation and study on hypoglycemicactivity of a series of <em>N</em>-(2-(4-methoxy-1-methyl/phenyl-2-oxo-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-<em>N</em>-substitutedprimaryamino) -benzenesulfononamides [IVa/b (1-6)]. Compounds exhibit prominent anti-diabetic activity by glucose oxidase peroxidase (GOD-POD) method which involves measurement of average serum glucose levels in mg/dl as well as conserved hydrogen bonds with one or more amino acid residues in the active pocket of murine 11β-hydroxysteroid dehydrogenase domain. Among all the synthesized compounds, compound <strong>IVb2</strong> shows prominent anti-diabetic activity and higher Moldock score as compared to standard drug Glibenclamide. Structural analysis of the synthesized compounds has been done by standard spectroscopic techniques.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-04-22 16:13:41
 
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http://op.niscair.res.in/index.php/IJC/article/view/62568
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 4 (2022): Indian Journal of Chemistry-(IJC)
 
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