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<p>Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds</p>

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Title Statement <p>Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds</p>
 
Added Entry - Uncontrolled Name Ramya, S ; Department of Organic Synthesis & Process Chemistry Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Anusha, K ; Centre for Natural Products & Traditional Knowledge CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Tiwari, A K ; Centre for Natural Products & Traditional Knowledge CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Raju, B China ; Department of Organic Synthesis & Process Chemistry Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
 
Uncontrolled Index Term Pyrazolines, pyrazoles, free-radical scavenging, α-glucosidase inhibitory activity
 
Summary, etc. <p class="Abstract" style="text-align: justify;">A total of fifty pyrazolines <strong>3a-y</strong> and pyrazoles <strong>4a-y</strong> have been evaluated for their free-radical scavenging and α-glucosidase inhibitory activities. The pyrazolines <strong>3e</strong>,<strong> 3h</strong>,<strong> 3p</strong>,<strong> 3s</strong> and pyrazole <strong>4e </strong>have been identified as potent ABTS.<sup>+ </sup>free-radical scavengers. The thiophene substituted pyrazoline <strong>3s</strong> has shown potent ABTS.<sup>+ </sup>free radical scavenging activity compared to thiophene substituted pyrazole <strong>4s</strong>. Furanyl (<strong>4r</strong>), pyrazolyl (<strong>4t</strong>), 2-chloropyridinyl (<strong>4u-w</strong>), 2-chloroquinolinyl (<strong>4x</strong>) and 4-chlorocoumarin (<strong>4y</strong>) pyrazoles have displayed moderate ABTS.<sup>+ </sup>free-radical scavenging activity. Pyrazoline <strong>3i</strong> and pyrazole <strong>4b</strong> have shown moderate DPPH<sup> </sup>free-radical scavenging activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-04-22 16:13:41
 
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http://op.niscair.res.in/index.php/IJC/article/view/62559
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 4 (2022): Indian Journal of Chemistry-(IJC)
 
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