Record Details

<p>Synthesis, antimicrobial and cytotoxicity studies of novel undecenoic acid-based triazolothiadiazole derivatives</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Synthesis, antimicrobial and cytotoxicity studies of novel undecenoic acid-based triazolothiadiazole derivatives</p>
 
Added Entry - Uncontrolled Name Venepally, Vijayendar ; Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Sirisha, K ; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Kumar, C Ganesh ; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Krishna, E Vamshi ; Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Mishra, Sunil ; Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
Jala, Ram Chandra Reddy; Centre for Lipid Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India
 
Uncontrolled Index Term Undecenoic acid, triazolothiadiazole, antimicrobial, cytotoxic, promising activities
 
Summary, etc. <p class="Abstract" style="text-align: justify;">In the present study, synthesis, antimicrobial and cytotoxic activity studies of 3,6-disubstituted-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole series compounds have been carried out. Compounds <strong>6d</strong>, <strong>6i</strong>, <strong>6k</strong>, <strong>6p</strong>, <strong>6q</strong>, <strong>6r</strong>, <strong>6s</strong> and <strong>6t</strong> exhibit promising activity with MIC value of 3.9 µg/mL against some of the tested bacterial strains. Compounds <strong>6r</strong> and <strong>6s</strong> consistently show promising minimum bactericidal concentration activity with MBC value of 7.8 µg/mL against <em>Staphylococcus</em><em> aureus </em>MTCC 96 strain. Cytotoxic evaluation study claims that most of the compounds exhibit significant cytotoxicity against all the studied cancer cell lines. Particularly, compounds <strong>6c</strong>, <strong>6k</strong>, <strong>6l</strong>, <strong>6n</strong> and <strong>6t</strong> against HeLa cell line and compounds <strong>6c</strong> and <strong>6h</strong> against B16-F10 cell line exhibit promising activities with IC<sub>50</sub> values ranging from 6.34 to 9.99 μM. Further, most of the compounds are non-toxic against Chinese hamster ovary cell (CHO-K1) normal cell.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-04-22 16:13:41
 
Electronic Location and Access application/pdf
application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/62567
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 4 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en