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<p>1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as <br /> antibacterial and anticancer agents</p>

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Title Statement <p>1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as <br /> antibacterial and anticancer agents</p>
 
Added Entry - Uncontrolled Name Vatsal, Manu ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India
Sharma, Anjali ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India
Awasthi, Pamita ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India
 
Uncontrolled Index Term Anthraquinone, cytotoxicity, prostate, cervix carcinoma, i-motif
 
Summary, etc. <p style="text-align: justify;">The new 1,5-disubstituted 9,10 anthraquninone compounds have been synthesized and characterized by FT-IR, <sup>1</sup>H and <sup>13</sup>C NMR,<sup> </sup>and mass spectrometry. Mass fragmentation pattern confirms the structure of the synthesized analogues. The synthesized compounds (B1-B5) have been found active against Hela (cervix carcinoma), prostate cancer and breast cancer cell lines in comparison to mitoxantrone. B2 screened out to be best. IC<sub>50</sub> value of B2 and mitoxantrone against Hela cell lines have been observed to be 17μg/mL and 2.5μg/mL respectively. DNA intercalation has been proposed as per cell cycle analysis of B2 on Hela cell lines which show major alteration in G0/G1 and S phase. The results are further supported by molecular docking study of (B1-B5) compounds and mitoxantrone with quadruplex terminals i-motif. The compounds have also been evaluated for antibacterial activities.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-04-22 16:13:41
 
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http://op.niscair.res.in/index.php/IJC/article/view/62579
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 4 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en