<p>1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as <br /> antibacterial and anticancer agents</p>
Online Publishing @ NISCAIR
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Authentication Code |
dc |
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Title Statement |
<p>1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as <br /> antibacterial and anticancer agents</p> |
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Added Entry - Uncontrolled Name |
Vatsal, Manu ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India Sharma, Anjali ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India Awasthi, Pamita ; Department of Chemistry, National Institute of Technology, Hamirpur 177 005, India |
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Uncontrolled Index Term |
Anthraquinone, cytotoxicity, prostate, cervix carcinoma, i-motif |
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Summary, etc. |
<p style="text-align: justify;">The new 1,5-disubstituted 9,10 anthraquninone compounds have been synthesized and characterized by FT-IR, <sup>1</sup>H and <sup>13</sup>C NMR,<sup> </sup>and mass spectrometry. Mass fragmentation pattern confirms the structure of the synthesized analogues. The synthesized compounds (B1-B5) have been found active against Hela (cervix carcinoma), prostate cancer and breast cancer cell lines in comparison to mitoxantrone. B2 screened out to be best. IC<sub>50</sub> value of B2 and mitoxantrone against Hela cell lines have been observed to be 17μg/mL and 2.5μg/mL respectively. DNA intercalation has been proposed as per cell cycle analysis of B2 on Hela cell lines which show major alteration in G0/G1 and S phase. The results are further supported by molecular docking study of (B1-B5) compounds and mitoxantrone with quadruplex terminals i-motif. The compounds have also been evaluated for antibacterial activities.</p> |
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Publication, Distribution, Etc. |
Indian Journal of Chemistry (IJC) 2022-04-22 16:13:41 |
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Electronic Location and Access |
application/pdf application/pdf http://op.niscair.res.in/index.php/IJC/article/view/62579 |
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Data Source Entry |
Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 4 (2022): Indian Journal of Chemistry-(IJC) |
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Language Note |
en |
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