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<p>HYSSOP and POLIUM could help to prevent COVID-19 in high-risk population: The results of a parallel randomized placebo-controlled field trial</p>

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Title Statement <p>HYSSOP and POLIUM could help to prevent COVID-19 in high-risk population: The results of a parallel randomized placebo-controlled field trial</p>
 
Added Entry - Uncontrolled Name Fazlju, Seyyed Mohammad Bagher
Ahmadian Heris, Javad
Farshbaf-Khalili, Azizeh
Khodadadi, Khodadad
Banagozar Mohammadi, Ahad
Shahabi, Parviz
Dorosti, Abbasali
Hamishekar, Hamed
Naghipour, Bahman
Pourfathi, Hojjat
Zahednia, Mohammad
Valizadeh, Einollah
Ranjbari, Yones
Zarei, Ahad
Sakaki, Ehsan
Ghassab-Abdollahi, Nafiseh
Salehi-Pourmehr, Hanieh
Safiri, Saeid
Tabriz University of Medical Sciences
 
Uncontrolled Index Term COVID-19, HYSSOP, Medicinal herbs, POLIUM, Prevention
 
Summary, etc. <p>This study was conducted to evaluate the effect of HYSSOP (composed of Hyssopus officinalis, Echium amoenum, and Glycyrrhiza glabra L) and POLIUM (contained Teucrium polium L, Cuscuta epithymum Murr, and Cichorium intybus L) combined distilled herbal medicines compared to placebo in prevention of COVID-19. This is a double-blind parallel placebo-controlled field trial conducted on 751 asymptomatic individuals who one of the family members recently had a positive RT-PCR test for COVID-19. They were divided into three groups including POLIUM, HYSSOP, and placebousing random blocks with a 1:1:1 allocation ratio. Participants received daily 5 cc (under 12 years) or 10 cc (over 12 years) of allocated oral medications for 20 days. The primary outcome was the frequency of positive RT-PCR test among participants who became symptomatic. The mean age of participants was 36.6. Nineteen participants get infected by COVID-19 during the intervention; fifteen of them belonged to the placebo and four to the POLIUM group. Fisher's exact test indicated significant differences between HYSSOP and placebo (p&lt;0.001) as well as POLIUM and placebo (p=0.009) groups in terms of COVID-19 confirmed by PCR test. Cox regression model adjusted for confounders illustrated that the hazard of getting infection by COVID-19 in POLIUM and HYSSOP groups decreased by 66% (OR (95% CI): 0.34 (0.12 to 0.94); p=0.038) and 93% (OR (95% CI): 0.07 (0.01to 0.56); p=0.012) respectively, compared to placebo. Oral administration of HYSSOP and POLIUM with the other supportive health care could decrease the risk of getting COVID-19. <strong></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2022-04-29 17:11:44
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/53424
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 21, ##issue.no## 2 (2022): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/53424/465573441
http://op.niscair.res.in/index.php/IJTK/article/download/53424/465573442
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http://op.niscair.res.in/index.php/IJTK/article/download/53424/465599171
http://op.niscair.res.in/index.php/IJTK/article/download/53424/465599172