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Effects of Se, Zn and Cu levels on chemoradiotherapy related toxicity in patients with locally advanced lung cancer

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Title Effects of Se, Zn and Cu levels on chemoradiotherapy related toxicity in patients with locally advanced lung cancer
 
Creator Cihan, Yasemin Benderli
Eser, Kadir
 
Subject Chemoradiotherapy (CRT)
Lung cancer
Trace elements
 
Description 315-321
Lung cancer, with 12% of overall new cancer cases globally, has considerable mortality rate. Chemotherapy and radiotherapy are the most common treatment modalities apart from surgery. Both, chemo- and radio- therapies, are known to have side affects. Trace elements are reported to influence the radiotherapy related adverse effects in the body. In this context, here, we investigated whether there is a difference in serum Se, Zn and Cu levels in patients receiving chemoradiotherapy (CRT) due to lung cancer when compared to healthy individuals and to evaluate effects of serum trace element levels measured before and after therapy on CRT related toxicity. This prospective study included 50 patients received CRT due to lung cancer and 50 healthy individuals. Serum selenium (Se), zinc (Zn), and copper (Cu) levels were measured before and after radiotherapy in patients with cancer, while a single measurement was performed in controls. When serum trace element levels were compared between patients with lung cancer and healthy controls, a significant difference was found in Zn level. A significant difference was detected between serum Cu and Se levels measured before and after CRT in patients with lung cancer (P
 
Date 2022-05-02T11:21:43Z
2022-05-02T11:21:43Z
2022-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/59640
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(05) [May 2022]