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Effects of Se, Zn and Cu levels on chemoradiotherapy related toxicity in patients with locally advanced lung cancer

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Title Statement Effects of Se, Zn and Cu levels on chemoradiotherapy related toxicity in patients with locally advanced lung cancer
 
Added Entry - Uncontrolled Name Cihan, Yasemin Benderli; Kayseri City Hospital, Department of Radiation Oncology, Şeker District, Muhsinyazıcıoğlu Boulevard, No:77, 38080 Kocasinan/Kayseri, Turkey Tel +90 352 315 77 00 - 01 - 02 Fax +90 352 315 79 86 H/P: +90 536 216 9987 Kayseri City Hospital, Department of Radiation Oncology, Şeker District, Muhsinyazıcıoğlu Boulevard, No:77, 38080 Kocasinan/Kayseri, Turkey Tel +90 352 315 77 00 - 01 - 02 Fax +90 352 315 79 86 H/P: +90 536 216 9987
Eser, Kadir ; Kayseri City Hospital, Department of Radiation Oncology, Şeker District, Muhsinyazıcıoğlu Boulevard, No:77, 38080 Kocasinan/Kayseri, Turkey Tel +90 352 315 77 00 - 01 - 02 Fax +90 352 315 79 86 H/P: +90 536 216 9987 Mersin State City Hospital, Department of Medical Oncology,
 
Uncontrolled Index Term Chemoradiotherapy (CRT); Lung cancer; Trace elements
 
Summary, etc. Lung cancer, with 12% of overall new cancer cases globally, has considerable mortality rate. Chemotherapy and radiotherapy are the most common treatment modalities apart from surgery. Both, chemo- and radio- therapies, are known to have side affects. Trace elements are reported to influence the radiotherapy related adverse effects in the body. In this context, here, we investigated whether there is a difference in serum Se, Zn and Cu levels in patients receiving chemoradiotherapy (CRT) due to lung cancer when compared to healthy individuals and to evaluate effects of serum trace element levels measured before and after therapy on CRT related toxicity. This prospective study included 50 patients received CRT due to lung cancer and 50 healthy individuals. Serum selenium (Se), zinc (Zn), and copper (Cu) levels were measured before and after radiotherapy in patients with cancer, while a single measurement was performed in controls. When serum trace element levels were compared between patients with lung cancer and healthy controls, a significant difference was found in Zn level. A significant difference was detected between serum Cu and Se levels measured before and after CRT in patients with lung cancer (P <0.001 and P =0.019). In the assessment of acute toxicity during, a significant difference was detected when Cu and Zn levels measured before and after treatment were compared. Our study indicates significant decreases in plasma Zn and Cu levels after radiotherapy, suggesting paying attention to nutritional status regarding these micronutrients and other antioxidant agents. Thus, Zn and Cu supplementation may reduce adverse effects in patients receiving CRT.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-05-04 17:03:29
 
Electronic Location and Access http://op.niscair.res.in/index.php/IJEB/article/view/34297
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 05 (2022): IJEB [May 2022]
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/34297/465506130