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Stevia aquatic extract protects the pancreas from streptozocin (STZ) induced damage: A stereological study

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Title Statement Stevia aquatic extract protects the pancreas from streptozocin (STZ) induced damage: A stereological study
 
Added Entry - Uncontrolled Name Dastghaib, Sanaz ; 1. Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 2.Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences,Shiraz, Iran.
koohpeyma, Farhad ; Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences,Shiraz, Iran.
khazayel, Saeed ; Department of Research and Technology of Kermanshah University of Medical Sciences, Kermanshah, Iran.
Gholizadeh, Fatemeh ; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mansoor pour, Soheila ; Endocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences,Shiraz, Iran.
Mokaram, Pooneh ; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Noorafshan, Ali ; Histomorphometry and Stereology Research Centre, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
This project was financed by Shiraz University of Medical Sciences with grant No 93-01-01-7178.
 
Uncontrolled Index Term Blood glucose; Candyleaf; Diabetes mellitus; Oxidative stress
 
Summary, etc. In recent years, among antidiabetic medicinal herbs, Stevia received a lot of attention due to its diverse therapeutic applications. Despite extensive reports on the effects of Stevia on the pancreas, its molecular mechanism is not clear yet. In this study, we investigated the protective and preventive effects of oral extracts of Stevia on the pancreas through the stereological methods in streptozocin (STZ) induced diabetic rats. Thus, 66 adult male rats were assigned to six groups (n = 11) viz., healthy control, healthy Stevia (400 mg /kg), diabetic-control, diabetic-metformin (500 mg/kg), diabetic-Stevia and pre-Stevia-diabetic group. Treatment with Stevia significantly reduced fasting blood sugar (FBS) and MDA compared to the diabetic control group (P <0.05). The results indicated that the weight and the volume of the pancreas increased significantly in all our treated groups compared to the diabetic one (P <0.05). The volume density of the pancreatic islands and the number of beta cells increased in healthy and diabetic groups treated with Stevia (P <0.05). However, the pre-treated diabetic rats with Stevia did not show significant preventive effects on the volume and number of beta cells as well as the volume of islets against destructive effects of STZ. More specifically, our results confirmed the protective effects of Stevia through restoring pancreatic cells and repairing the stereological damage induced by STZ.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-05-04 17:03:29
 
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http://op.niscair.res.in/index.php/IJEB/article/view/35447
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 05 (2022): IJEB [May 2022]
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/35447/465509870
http://op.niscair.res.in/index.php/IJEB/article/download/35447/465509872
http://op.niscair.res.in/index.php/IJEB/article/download/35447/465510851
http://op.niscair.res.in/index.php/IJEB/article/download/35447/465510870