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Protective effect of eugenol from Mesua ferrea on the oxidative damages caused by 5-fluorouracil in PBMC cells

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Title Protective effect of eugenol from Mesua ferrea on the oxidative damages caused by 5-fluorouracil in PBMC cells
 
Creator Surendhira, Sathees
Arjun, Mani Murugan
Steven, Benhur
Rajalakshmi, Perumal
Vadivel, Vellingiri
 
Subject 5-Fluorouracil
Cytoprotective effect
Eugenol
Mesua ferrea
ROS toxicity
 
Description 78-85
5-Fluorouracil (5-FU), a pyrimidine analogue with fluorine at C5 position, is one of the chemotherapy drugs used to treat
various cancers. Though 5-FU is a very promising anticancer drug, it can cause side effects such as coronary thrombosis,
intestinal mucositis, cognitive impairment, and anaemia through the generation of free radicals, damages the normal cells and
also leads to apoptosis. To overcome such toxic effects of 5-FU, in the present work we have explored the cytoprotective
potential of eugenol, the antioxidant active compound available in ethanolic extract of an Indian herbal drug Mesua ferrea. Aim
of the present study was to evaluate the cytoprotective effect of eugenol against 5-FU toxicity in peripheral blood mononuclear
cells (PBMC). Based on MTT assay, it is noticed that eugenol significantly prevents the toxicity of 5-FU (73%) in PBMC cells.
Eugenol has lowered the generation of intra-cellular ROS (20035.5 AU) when compared to 5-FU treated cells (58918.5 AU).
Eugenol exhibited remarkable inhibition of lipid peroxidation (43%) and cell membrane damage (LDH release: 488.02 IU/L).
Thus, eugenol prevents apoptosis-induced cell death when compared with 5-FU in PBMC cells and hence it can be used to
overcome the cytotoxicity caused by 5-FU and it warrants further study.
 
Date 2022-05-12T08:54:04Z
2022-05-12T08:54:04Z
2022-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59693
 
Language en
 
Relation Int. cl. (2021.01)-A61K 36/00, A61P
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.13(1) [March 2022]