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Neuroprotective effect of Canthium parviflorum on streptozotocin induced diabetic neuropathy in rats

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Title Neuroprotective effect of Canthium parviflorum on streptozotocin induced diabetic neuropathy in rats
 
Creator Jeedi, Neelakanth M.
Koti, Basavaraj C
 
Subject Antidiabetic
Canthium parviflorum
Diabetic neuropathy
Neuroprotective
Streptozotocin
 
Description 45-51
In traditional system to cure diabetes and related complications, Canthium parviflorum Lam plant leaves are used.
Ethanolic extract of leaves were considered to investigate its neuroprotective property in streptozotocin elicited diabetic
neuropathy rat model. Streptozotocin (60 mg/kg body weight) given by intraperitoneal injection to induce diabetes, with no
treatment given, was intended to develop diabetic neuropathy. Fourteen days after induction, animals were given the extract
(100 and 200 mg/kg) once daily for thirty five days. Hypersensitivity to temperature in diabetic neuropathy was assessed by
tail immersion and eddy’s hot plate tests. Nerve growth factor, blood glucose, and pro-inflammatory cytokines involved in
pathological pain were measured in sciatic nerve. Neuropathy which is also associated with oxidative stress was assessed by
measuring bio-markers in sciatic tissue. Diabetic induced neuropathic animals exhibited significant decrease in the paw and
tail withdraw time thus signifying diabetic neuropathy. Extract treatment prevented diabetic neuropathy in animals thus
showing normalized response to hot and cold. These actions in extract treatment groups are supported evidently by normal
blood glucose, significant low levels of pro-inflammatory cytokines, oxidative stress bio-markers, and high nerve growth
factor in sciatic nerve tissue. C. parviflorum leaves ethanolic extract display neuroprotective effect in STZ-induced diabetic
neuropathy in rats.
 
Date 2022-05-12T09:04:56Z
2022-05-12T09:04:56Z
2022-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59698
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/74, A61K 127/00, A61P 25/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.13(1) [March 2022]