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Cassava starch film loaded with extract of Piper betel leaf for anti-inflammatory activity

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Title Cassava starch film loaded with extract of Piper betel leaf for anti-inflammatory activity
 
Creator Nagargoje, Sadhana
Patole, Vinita
Awari, Devyani
 
Subject Anti-inflammatory activity
Cassava starch
Diclofenac sodium
Piper betel
Transdermal film
 
Description 36-44
The aim of the present research work was to formulate a transdermal film of Piper betel L. leaf extract along with
diclofenac sodium and evaluate its anti-inflammatory activity. The ethanolic extract of P. betel leaf was obtained by solvent
extraction method using a Soxhlet apparatus. The P. betel leaf extract was analysed for inhibition of the albumin
denaturation and it showed a significant inhibition of the albumin denaturation. The topical film was then prepared by
solvent casting method using diclofenac sodium and P. betel leaf extract. The film was evaluated for drug content, thickness,
weight uniformity, folding endurance, moisture content, moisture uptake, and barrier properties of the film. The formulated
film was thin, flexible, and possessed satisfactory physicochemical properties. The anti-inflammatory potential of the film
was evaluated by using carrageenan-induced rat paw oedema method on albino Wistar rats. The anti-inflammatory activity
of film was found comparable with standard diclofenac sodium film and exhibited inhibition of oedema within 4 h. This
signifies that the combination of P. betel leaf extract and diclofenac sodium has remarkable potential to serve as synergistic
topical anti-inflammatory film preparation than simple topical film formulation of diclofenac sodium.
 
Date 2022-05-12T09:06:53Z
2022-05-12T09:06:53Z
2022-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59699
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 127/00, A61P 29/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.13(1) [March 2022]