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Cytotoxic constituents from Vietnamese Pterospermum truncatolobatum Gagnep.

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Title Cytotoxic constituents from Vietnamese Pterospermum truncatolobatum Gagnep.
 
Creator Linh, Le Thi Khanh
Uyen, Nguyen Thu
Dien, Pham Huu
Quang, Dang Ngoc
 
Subject Betulonic acid
Cancer
Cytotoxic
Medicinal plant
Pterospermum truncatolobatum Gagnep
Taraxerol.
 
Description 32-35
Pterospermum truncatolobatum Gagnep. has long been used as a traditional medicine in Vietnam. Its crude extract
showed cytotoxicity against human epidermal carcinoma (KB) cell lines. However, its chemical constituent and biological
activity remains unknown. In the course of our investigation on the Vietnamese medicinal plants, four compounds, taraxerol
(1), betulonic acid (2), -sitosterol (3) and eicosanoic acid (4) were purified from methanolic extract of P. truncatolobatum
by silica gel column chromatography. Their structures were determined by spectral (Mass spectrometry and nuclear
magnetic resonance) analysis and by comparison with the literature reports. Of which, betulonic acid (2) showed moderate
cytotoxicity against all four cancer cell lines, KB, MCF7 (human breast carcinoma), LU (human lung carcinoma), and HepG2
(hepatocellular carcinoma).
 
Date 2022-05-12T09:09:47Z
2022-05-12T09:09:47Z
2022-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59700
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 127/00, A61K 135/00, A61P
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.13(1) [March 2022]