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Antidepressant and anxiolytic activities of Cochlospermum religiosum leaf extract, synergism with antidepressants, and molecular docking studies

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Title Antidepressant and anxiolytic activities of Cochlospermum religiosum leaf extract, synergism with antidepressants, and molecular docking studies
 
Creator Gari, Sreelakshmi Bada Venkatappa
Bhatt, Shvenkat
Kutagulla, Vinay Kumar
Reddy, Kanala Somasekhar
 
Subject Antidepressant
Anxiolytic
Cochlospermum religiosum
Molecular docking
Reserpine
Synergism.
 
Description 23-31
The leaves of Cochlospermum religiosum were investigated for the antidepressant and anxiolytic activities in mice using
behavioural models like spontaneous locomotor activity, forced swim test, tail suspension test, elevated plus maze and
marble burying behaviour. The mechanism was studied using Reserpine-induced hypothermia (RIH) model and in silico
molecular docking. The leaf extract exhibited significant antidepressant and anxiolytic effects (P
 
Date 2022-05-12T09:12:04Z
2022-05-12T09:12:04Z
2022-03
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59701
 
Language en
 
Relation Int. cl. (2021.01)-A61K 36/00, A61K 127/00, A61P 25/00, A61P 25/22, A61P 25/24
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.13(1) [March 2022]