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<p style="text-align: justify;">Protective effect of eugenol from <em>Mesua ferrea</em> on the oxidative damages caused by 5-fluorouracil in PBMC cells</p>

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Title Statement <p style="text-align: justify;">Protective effect of eugenol from <em>Mesua ferrea</em> on the oxidative damages caused by 5-fluorouracil in PBMC cells</p>
 
Added Entry - Uncontrolled Name Surendhiran, Sathees ; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
Arjun, Mani Murugan ; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
Steven, Benhur ; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
Rajalakshmi, Perumal ; Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
Vadivel, Vellingiri ; Chemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
 
Uncontrolled Index Term 5-Fluorouracil; Cytoprotective effect; Eugenol; Mesua ferrea; ROS toxicity.
 
Summary, etc. <p style="text-align: justify;">5-Fluorouracil (5-FU), a pyrimidine analogue with fluorine at C5 position, is one of the chemotherapy drugs used to treat various cancers. Though 5-FU is a very promising anticancer drug, it can cause side effects such as coronary thrombosis, intestinal mucositis, cognitive impairment, and anaemia through the generation of free radicals, damages the normal cells and also leads to apoptosis. To overcome such toxic effects of 5-FU, in the present work we have explored the cytoprotective potential of eugenol, the antioxidant active compound available in ethanolic extract of an<em> </em>Indian herbal drug <em>Mesua ferrea</em>. Aim of the present study was to evaluate the cytoprotective effect of eugenol against 5-FU toxicity in peripheral blood mononuclear cells (PBMC). Based on MTT assay, it is noticed that eugenol significantly prevents the toxicity of 5-FU (73%) in PBMC cells. Eugenol has lowered the generation of intra-cellular ROS (20035.5 AU) when compared to 5-FU treated cells (58918.5 AU). Eugenol exhibited remarkable inhibition of lipid peroxidation (43%) and cell membrane damage (LDH release: 488.02 IU/L). Thus, eugenol prevents apoptosis-induced cell death when compared with 5-FU in PBMC cells and hence it can be used to overcome the cytotoxicity caused by 5-FU and it warrants further study.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-05-23 16:40:13
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/40740
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 1 (2022): MARCH 2022
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/40740/465608761
 
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