Record Details

<p style="text-align: justify;">Antidepressant and anxiolytic activities of <em>Cochlospermum religiosum</em> leaf extract, synergism with antidepressants, and molecular docking studies</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Antidepressant and anxiolytic activities of <em>Cochlospermum religiosum</em> leaf extract, synergism with antidepressants, and molecular docking studies</p>
 
Added Entry - Uncontrolled Name Bada Venkatappa Gari, Sreelakshmi ; Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, (Affiliated to JNT University Anantapur), Anantapur 515721, Andhra Pradesh, India
Bhatt, Shvenkat ; Amity Institute of Pharmacy, Amity University, Gwalior 474005, Madhya Pradesh, India
Kutagulla, Vinay Kumar; Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, (Affiliated to JNT University Anantapur), Anantapur 515721, Andhra Pradesh, India
Kanala, Somasekhar Reddy ; Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, (Affiliated to JNT University Anantapur), Anantapur 515721, Andhra Pradesh, India
Yiragamreddy, Padmanabha Reddy ; Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, (Affiliated to JNT University Anantapur), Anantapur 515721, Andhra Pradesh, India
Peraman, Ramalingam ; National Institute of Pharmaceutical Education and Research (NIPER), Hajipur 844102, Bihar, India
Nil
 
Uncontrolled Index Term Pharmacology; Natural products
Antidepressant; Anxiolytic; Cochlospermum religiosum; Molecular docking; Reserpine; Synergism.
 
Summary, etc. <p style="text-align: justify;">The leaves of <em>Cochlospermum religiosum </em>were investigated for the antidepressant and anxiolytic activities in mice using behavioural models like spontaneous locomotor activity, forced swim test, tail suspension test, elevated plus maze and marble burying behaviour. The mechanism was studied using Reserpine-induced hypothermia (RIH) model and <em>in silico </em>molecular docking. The leaf extract exhibited significant antidepressant and anxiolytic effects (<em>P </em>&lt;0.05 for 50 mg/kgb.w.,p.o./<em>P </em>&lt;0.01 for 100 mg/kgb.w., p.o.) in mice without an impact on baseline locomotor activity. The result from Reserpine-induced hypothermia rat model revealed that the leaf extract (50 mg/kgb.w., p.o.) significantly antagonized the effect (<em>P </em>&lt;0.05) of Reserpine. Furthermore, synergistic effect was evaluated by coadministration of the leaf extracts with fluoxetine (10 mg/kg, i.p.) and imipramine (10 mg/kg, i.p.) at sub-therapeutic dose levels. Synergistic effect of the leaf extract was significant (<em>P </em>&lt;0.05) for both antidepressant and anxiolytic activities as compared to therapeutic doses of extract, imipramine, and fluoxetine. The molecular docking studies for the chemical constituents of the leaves on 5HT1B, 5HT2A, β1 and β2 crystal structures revealed that pentagalloyl glucose showed typical binding with higher affinity on 5HT1B (-10.79) and 5HT2A(-10.33) than fluoxetine and imipramine. Cynarine docked on β-2 receptor with score of -13.582 at binding site of timolol, and similarly, it binds with 5HT1B and 5HT2A at serotonin binding site.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-05-23 16:40:13
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/37694
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 1 (2022): MARCH 2022
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/37694/465516961
http://op.niscair.res.in/index.php/IJNPR/article/download/37694/465516962
http://op.niscair.res.in/index.php/IJNPR/article/download/37694/465516964
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.