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<p style="text-align: justify;">Cytotoxic constituents from Vietnamese <em>Pterospermum truncatolobatum</em> Gagnep.</p>

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Title Statement <p style="text-align: justify;">Cytotoxic constituents from Vietnamese <em>Pterospermum truncatolobatum</em> Gagnep.</p>
 
Added Entry - Uncontrolled Name Linh, Le Thi Khanh; Faculty of Chemistry, Hanoi National University of Education, 136-Xuan Thuy road, Cau Giay, Hanoi 10000, Vietnam
Uyen, Nguyen Thu; Faculty of Chemistry, Hanoi National University of Education, 136-Xuan Thuy road, Cau Giay, Hanoi 10000, Vietnam
Dien, Pham Huu; Faculty of Chemistry, Hanoi National University of Education, 136-Xuan Thuy road, Cau Giay, Hanoi 10000, Vietnam
Quang, Dang Ngoc; Faculty of Chemistry, Hanoi National University of Education, 136-Xuan Thuy road, Cau Giay, Hanoi 10000, Vietnam
 
Uncontrolled Index Term Isolation, structural elucidation, biological activity
Betulonic acid; Cancer; Cytotoxic; Medicinal plant; Pterospermum truncatolobatum Gagnep.; Taraxerol.
 
Summary, etc. <p style="text-align: justify;"><em>Pterospermum truncatolobatum</em> Gagnep. has long been used as a traditional medicine in Vietnam. Its crude extract showed cytotoxicity against human epidermal carcinoma (KB) cell lines. However, its chemical constituent and biological activity remains unknown. In the course of our investigation on the Vietnamese medicinal plants, four compounds, taraxerol (<strong>1</strong>), betulonic acid (<strong>2</strong>), <em>b</em>-sitosterol (<strong>3</strong>) and eicosanoic acid (<strong>4</strong>) were purified from methanolic extract of <em>P. truncatolobatum</em> by silica gel column chromatography. Their structures were determined by spectral (<em>Mass spectrometry</em> and<em> </em><em>nuclear magnetic resonance</em>) analysis and by comparison with the literature reports. Of which, betulonic acid (<strong>2</strong>) showed moderate cytotoxicity against all four cancer cell lines, KB, MCF7 (human breast carcinoma), LU (human lung carcinoma), and HepG2 (hepatocellular carcinoma).</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-05-23 16:40:13
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/42120
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 1 (2022): MARCH 2022
 
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