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<p style="text-align: justify;">Cassava starch film loaded with extract of <em>Piper betel </em>leaf for anti-inflammatory activity</p>

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Title Statement <p style="text-align: justify;">Cassava starch film loaded with extract of <em>Piper betel </em>leaf for anti-inflammatory activity</p>
 
Added Entry - Uncontrolled Name Nagargoje, Sadhana
Patole, Vinita ; Department of Pharmaceutics, Dr D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, Maharashtra, India
Awari, Devyani ; Department of Pharmacology, Datta Meghe College of Pharmacy, Salod (H), Sawangi, Wardha 442004, Maharashtra, India
Savitribai Phule Pune University, Pune
 
Uncontrolled Index Term Anti-inflammatory activity; Cassava starch; Diclofenac sodium; Piper betel; Transdermal film.
 
Summary, etc. <p style="text-align: justify;">The aim of the present research work was to formulate a transdermal film of <em>Piper betel</em> L. leaf extract along with diclofenac sodium and evaluate its anti-inflammatory activity. The ethanolic extract of <em>P. betel </em>leaf was obtained by solvent extraction method using a Soxhlet apparatus. The <em>P. betel</em> leaf extract was analysed for inhibition of the albumin denaturation and it showed a significant inhibition of the albumin denaturation. The topical film was then prepared by solvent casting method using diclofenac sodium and <em>P. betel </em>leaf extract. The film was evaluated for drug content, thickness, weight uniformity, folding endurance, moisture content, moisture uptake, and barrier properties of the film. The formulated film was thin, flexible, and possessed satisfactory physicochemical properties. The anti-inflammatory potential of the film was evaluated by using carrageenan-induced rat paw oedema method on albino Wistar rats. The anti-inflammatory activity of film was found comparable with standard diclofenac sodium film and exhibited inhibition of oedema within 4 h. This signifies that the combination of <em>P. betel</em> leaf extract and diclofenac sodium has remarkable potential to serve as synergistic topical anti-inflammatory film preparation than simple topical film formulation of diclofenac sodium.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-05-23 16:40:13
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/44492
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 1 (2022): MARCH 2022
 
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http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541920
http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541921
http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541922
http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541923
http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541924
http://op.niscair.res.in/index.php/IJNPR/article/download/44492/465541925
 
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