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Biochemical relationship between leiomyosarcoma and peroxiredoxin-6 expression level: Clinical implications

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Title Biochemical relationship between leiomyosarcoma and peroxiredoxin-6 expression level: Clinical implications
 
Creator Herkiloglu, Dilsad
Gokce, Sefik
Kaygusuz, Ecmel Isık
Cevik, Ozge
Ahmad, Sarfraz
 
Subject Biomarker
Clinical relevance
Histopathology
Leomyosarcoma
Myoma
Peroxiredoxin-6
Prognosis
 
Description 552-527
Uterine leiomyosarcomas are tumors with a heterogeneous genetic profiles that respond very poorly to cytotoxic
chemotherapy with aggressive progression. We aimed to show the status of peroxiredoxin 6 as a biomarker in leiomyosarcoma
progression.Study included 12 patients diagnosed with "leiomyosarcoma" and 13 patients diagnosed with "myoma" (as control)
after histopathological examinations of clinical samples. Peroxiredoxin-6 gene expression and protein levels were evaluated on
the tumor preparations (blocks) utilizing ELISA and PCR methods.Peroxiredoxin-6 protein was mainly localized in the
cytoplasm of leiomyosarcoma cells, and the expression of peroxiredoxin-6 was significantly increased in cancerous tissues
compared to normal myoma tissues (3.33±1.7 vs. 2.03±1.07fold change; P= 0.031). Peroxiredoxin-6 tissue protein levels were
also significantly higher in leiomyosarcoma cases (100.54±66.86 vs. 183.72±64.54 pg/μg protein; P= 0.005). Our findings
demonstrate that peroxiredoxin-6 plays a vital role in the emergence and development of leiomyosarcoma and that
peroxiredoxin-6 level assessments can be used as a biomarker in guiding better prognosis andtreatment plans while managing
leiomyosarcoma.
 
Date 2022-05-26T11:36:43Z
2022-05-26T11:36:43Z
2022-05
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59770
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(5) [May 2022]