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Structure-function relationships among selected human coronaviruses

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Title Structure-function relationships among selected human coronaviruses
 
Creator Jamir, Esther
Kiewhuo, Kikrusenuo
Priyadarsinee, Lipsa
Sarma, Himakshi
Nagamani, Selvaraman
Sastry, G Narahari
 
Subject Hotspot residues
Multiple sequence alignment
Protein-protein interaction
Seven human coronaviruses
 
Description 536-551
Identifying the key proteins among different types of human disease-causing coronaviruses is essential for the molecular
mechanism and thereby designing potential drug molecules. Eight selected proteins of seven types of disease-causing
coronaviruses, viz.SARS-CoV-2 (severe acute respiratory syndrome coronavirus2), SARS-CoV (severe acute respiratory
syndrome coronavirus), MERS-CoV (middle east respiratory syndrome coronavirus), Human coronavirus OC43, Human
coronavirus HKU1, Human coronavirus 229E and Human coronavirus NL63, were chosen for the comparison. Further, an
attempt has been made to explore the most important host-pathogen interactions with a special focus on spike (RBD) protein
region as this region deemed to be functionally most important. Epitope region was also identified which helps in the design
of epitope-based vaccines. The structural comparison carried out among the seven types of human coronaviruses has
revealed the molecular level details on the similarity among this series. This study has facilitated the identification of the
important residues in the studied proteins which control the key functions such as viral replication and transmission. Thus,
exploring the protein space in the family of coronaviruses, provide valuable insights into the molecular basis associated with
the role of proteins and viral infections, which is expected to trigger the identification of the drug targets for coronaviruses
infections, in a rational way.
 
Date 2022-05-26T11:40:22Z
2022-05-26T11:40:22Z
2022-05
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59771
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(5) [May 2022]