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Evolution of modern age drug discovery of lipopeptides and computer-aided drug discovery in India

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Title Evolution of modern age drug discovery of lipopeptides and computer-aided drug discovery in India
 
Creator Yadav, Manisha
Eswari, J Satya
 
Subject Antimicrobial resistance
Computer-aided drug discovery
Evolution of drug discovery
Lipopeptides
Microbial metabolites
Role of Indian pharmaceuticals
 
Description 503-508
The endeavor has been attempted to present a review on the evolution of modern age drug discovery in India. The
contribution of next generation therapeutics options microbial metabolites and the computational drug discovery aspects to
the global market from India have been represented. Microbial metabolites such as lipopeptides and peptide therapeutics are
gaining worldwide importance due to their multiple applications as broad-spectrum antimicrobial, antiviral, anticancer
properties etc. Due to the surge of microbial resistance, tumor resistance, and ongoing pandemic due to constantly mutating
corona virus, there is a need to develop next-generation therapeutics options from natural origin, less toxic to the
environment, and have higher specificity towards target. Small molecule therapeutics are certainly less specific towards
cancer targets hence the cytotoxicity is a major issue in cancer treatment while drug resistance due to the mutations are
coming as challenges every day for drug discovery researchers. Microbial lipopeptide reserves a sweet spot in between the
small molecule inhibitors and peptide therapeutics because of their amphiphilic compounds consist of a fatty acid side chain
and a cyclic peptide moiety of hydrophilic nature. The computational drug discovery approach accelerates the drug
discovery process due to the advancement in supercomputer facilities provided by various funding agencies such as the
Department of Biotechnology (DBT) and the Department of Science and Technology (DST) in India. The current review
article is focusing light on the research contribution of Indian Scientists and Govt. of India in the field of lipopeptide-based
research and applications of Computer-aided drug discovery.
 
Date 2022-05-26T11:51:49Z
2022-05-26T11:51:49Z
2022-05
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59775
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(5) [May 2022]