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Synthesis, antimicrobial and docking studies of some novel (N1E, N2E)-N1, N2-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines

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Title Synthesis, antimicrobial and docking studies of some novel (N1E, N2E)-N1, N2-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines
 
Creator Usha, V
Thirunarayanan, G
Manikandan, S
 
Subject Schiff base
IR
NMR
antibacterial activities
docking study
 
Description 521-527
The diamino derivative is utilized to synthesize various substituted derivatives, which are characterized by IR and NMR. The antibacterial properties of synthesized compounds have been explored. Novel (E)-4,6-dibromo-N1- (4-substitutedbenzylidene)benzene-1,2-diamine derivatives (1-6) have been obtained in good yields from 2-amino- 3,5-dibromobenzaldehyde and 4-substituted benzene-1,2 diamines in a single pot synthesis. The antimicrobial activity of the synthesized compounds have been screened against different strains such as Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli and compared with Ciprofloxacin as a standard and compound 6 shows significant activity against Staphylococcus aureus. The docking study results also support the antimicrobial activity data.
 
Date 2022-05-31T06:49:04Z
2022-05-31T06:49:04Z
2022-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/59814
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(05) [May 2022]