Synthesis, antimicrobial and docking studies of some novel (N1E, N2E)-N1, N2-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines
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Title |
Synthesis, antimicrobial and docking studies of some novel (N1E, N2E)-N1, N2-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines
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Creator |
Usha, V
Thirunarayanan, G Manikandan, S |
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Subject |
Schiff base
IR NMR antibacterial activities docking study |
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Description |
521-527
The diamino derivative is utilized to synthesize various substituted derivatives, which are characterized by IR and NMR. The antibacterial properties of synthesized compounds have been explored. Novel (E)-4,6-dibromo-N1- (4-substitutedbenzylidene)benzene-1,2-diamine derivatives (1-6) have been obtained in good yields from 2-amino- 3,5-dibromobenzaldehyde and 4-substituted benzene-1,2 diamines in a single pot synthesis. The antimicrobial activity of the synthesized compounds have been screened against different strains such as Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli and compared with Ciprofloxacin as a standard and compound 6 shows significant activity against Staphylococcus aureus. The docking study results also support the antimicrobial activity data. |
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Date |
2022-05-31T06:49:04Z
2022-05-31T06:49:04Z 2022-05 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/59814 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.61(05) [May 2022]
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