A catalytic three-component synthesis of isoxazol-5(4H)-ones under green conditions
NOPR - NISCAIR Online Periodicals Repository
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Title |
A catalytic three-component synthesis of isoxazol-5(4H)-ones under green conditions
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Creator |
Gharehassanlou, Sanaz
Kiyani, Hamzeh |
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Subject |
Green synthesis
isoxazol-5(4H)-ones sodium malonate β-ketoester three-component cyclocondensation |
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Description |
515-520
The three-component cyclocondensation of various aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/ethyl 4-chloro-3-oxobutanoate have been established for the synthesis of isoxazol-5(4H)-ones using sodium malonate as an efficient catalyst. This reaction has been performed in water as a green reaction medium at 25°C. Optimization of the reaction conditions show that the reaction performs better in aqueous medium, at room temperature, and in the presence of 10 mol% of the catalyst. This procedure has several unique features, including shorter reaction times, easy separation of pure products, avoiding the hazardous organic solvents, simplicity of experimental procedures, operationally simple, and eco-friendly. |
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Date |
2022-05-31T06:50:36Z
2022-05-31T06:50:36Z 2022-05 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/59815 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.61(05) [May 2022]
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