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A catalytic three-component synthesis of isoxazol-5(4H)-ones under green conditions

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Title A catalytic three-component synthesis of isoxazol-5(4H)-ones under green conditions
 
Creator Gharehassanlou, Sanaz
Kiyani, Hamzeh
 
Subject Green synthesis
isoxazol-5(4H)-ones
sodium malonate
β-ketoester
three-component cyclocondensation
 
Description 515-520
The three-component cyclocondensation of various aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl
acetoacetate/ethyl 4-chloro-3-oxobutanoate have been established for the synthesis of isoxazol-5(4H)-ones using sodium
malonate as an efficient catalyst. This reaction has been performed in water as a green reaction medium at 25°C.
Optimization of the reaction conditions show that the reaction performs better in aqueous medium, at room temperature, and
in the presence of 10 mol% of the catalyst. This procedure has several unique features, including shorter reaction times, easy
separation of pure products, avoiding the hazardous organic solvents, simplicity of experimental procedures, operationally
simple, and eco-friendly.
 
Date 2022-05-31T06:50:36Z
2022-05-31T06:50:36Z
2022-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/59815
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(05) [May 2022]