ICAR Research Data Repository for Knowledge Management
Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride
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| Creator |
Ganesh, N S
Spandana, K V L D Narsaiah, A Venkat |
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| Subject |
Wittig reaction
CBS-reduction oxidation reductive amination hyperparathyroidism |
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| Description |
503-507
A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination. |
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| Date |
2022-05-31T06:56:39Z
2022-05-31T06:56:39Z 2022-05 |
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| Type |
Article
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| Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/59817 |
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| Language |
en
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| Publisher |
NIScPR-CSIR, India
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| Source |
IJC Vol.61(05) [May 2022]
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