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<p>A catalytic three-component synthesis of isoxazol-5(4<em>H</em>)-ones under green conditions</p>

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Title Statement <p>A catalytic three-component synthesis of isoxazol-5(4<em>H</em>)-ones under green conditions</p>
 
Added Entry - Uncontrolled Name Gharehassanlou, Sanaz ; School of Chemistry, Damghan University, Damghan 36716-41167, Iran
Kiyani, Hamzeh ; School of Chemistry, Damghan University, Damghan 36716-41167, Iran
 
Uncontrolled Index Term Green synthesis, isoxazol-5(4H)-ones, sodium malonate, β-ketoester, three-component cyclocondensation
 
Summary, etc. <p class="Abstract" style="text-align: justify;"><span lang="EN-GB">The three-component cyclocondensation of various aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/</span><span lang="EN-GB">ethyl 4-chloro-3-oxobutanoate<span> have been established for the synthesis of isoxazol-5(4<em>H</em>)-ones using sodium malonate as an efficient catalyst. This reaction has been performed in water as a green reaction medium at 25°C. Optimization of the reaction conditions show that the reaction performs better in aqueous medium, at room temperature, and in the presence of 10 mol% of the catalyst. This procedure has several unique features, including shorter reaction times, easy separation of pure products, avoiding the hazardous organic solvents, simplicity of experimental procedures, operationally simple, and eco-friendly.</span></span></p><br />
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-05-31 17:21:39
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/63643
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 5 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en