Record Details

<h3>Enantioselective synthesis of hyperparathyroidism agent Cinacalcet <br /> hydrochloride</h3>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <h3>Enantioselective synthesis of hyperparathyroidism agent Cinacalcet <br /> hydrochloride</h3>
 
Added Entry - Uncontrolled Name Ganesh, N S ; Organic Synthesis Laboratory, Fluoro-Agrochemicals Department, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Spandana, K V L D ; Organic Synthesis Laboratory, Fluoro-Agrochemicals Department, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Narsaiah, A Venkat ; Organic Synthesis Laboratory, Fluoro-Agrochemicals Department, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
 
Uncontrolled Index Term Wittig reaction, CBS-reduction, oxidation, reductive amination, hyperparathyroidism
 
Summary, etc. <p style="text-align: justify;">A simple and efficient route has been developed for<strong> </strong>enantioselective synthesis of hyperparathyroidism agent (<em>R</em>)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-05-31 17:21:39
 
Electronic Location and Access application/pdf
application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/63641
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 5 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en