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<p>Synthesis, antimicrobial and docking studies of some novel (<em>N<sup>1</sup>E</em>,<em> N<sup>2</sup>E)-N<sup>1</sup></em>, <em>N<sup>2</sup></em>-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines</p>

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Title Statement <p>Synthesis, antimicrobial and docking studies of some novel (<em>N<sup>1</sup>E</em>,<em> N<sup>2</sup>E)-N<sup>1</sup></em>, <em>N<sup>2</sup></em>-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines</p>
 
Added Entry - Uncontrolled Name Usha, V ; Department of Chemistry, University College of Engineering Panruti, Panruti 607 106, India
Thirunarayanan, G ; Department of Chemistry, Annamalai University, Chidambaram 608 002, India
Manikandan, S ; Department of Chemistry, Annamalai University, Chidambaram 608 002, India
 
Uncontrolled Index Term Schiff base, IR, NMR, antibacterial activities, docking study
 
Summary, etc. <p style="text-align: justify;">The diamino derivative is utilized to synthesize various substituted derivatives, which are characterized by IR and NMR. The antibacterial properties of synthesized compounds have been explored. Novel (E)-4,6-dibromo-N1- (4-substitutedbenzylidene)benzene-1,2-diamine derivatives (<strong>1-6</strong>) have been obtained in good yields from 2-amino-3,5-dibromobenzaldehyde and 4-substituted benzene-1,2 diamines in a single pot synthesis. The antimicrobial activity of the synthesized compounds have been screened against different strains such as <em>Staphylococcus aureus</em>, <em>Bacillus subtilis</em>, <em>Streptococcus pyogenes</em>, <em>Klebsiella pneumoniae</em>, <em>Escherichia coli</em> and compared with Ciprofloxacin as a standard and compound <strong>6</strong> shows significant activity against <em>Staphylococcus aureus</em>. The docking study results also support the antimicrobial activity data.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-05-31 17:21:39
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/63644
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 5 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en