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<p>Synthesis of pyrimidine linked heterocyclic scaffolds by intramolecular cyclization and study of biological potential</p>

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Title Statement <p>Synthesis of pyrimidine linked heterocyclic scaffolds by intramolecular cyclization and study of biological potential</p>
 
Added Entry - Uncontrolled Name Deohate, Pradip P; Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola 444 001, India
Palaspagar, Kalpana A; Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola 444 001, India
 
Uncontrolled Index Term Synthesis, pyrimidine linked heterocyclic scaffolds, biological potential
 
Summary, etc. <p style="text-align: justify;">Synthesis of some interesting pyrimidine linked heterocyclic scaffolds by intramolecular cyclization has been worked out. Initially compound (4,6-dimethyl-pyrimidin-2-yl-amino)-acetic acid hydrazide has been prepared by reacting 2-amino-4,6-dimethyl pyrimidine with ethyl chloroacetate, followed by condensation with hydrazine hydrate. It has then been treated with N-aryl/alkyl isothiocyanates, followed by intramolecular cyclization using alkaline ethanolic solution of I<sub>2</sub> with KI, <em>o</em>-phosphoric acid and aqueous KOH to afford respective heterocyclic compounds with differently substituted pharmacophores <em>viz</em>. (5-aryl/alkyl-amino-[1,3,4]-oxadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines, (5-aryl/alkyl-amino-[1,3,4]-thiadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines and (4-aryl/alkyl-5-mercapto-[1,2,4]-triazol-3-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines. Developments during the synthesis have been monitored by TLC. Constitution of synthesized compounds have been delineated in accordance with equivalent weight, elemental assay,chemical transformation and IR, <sup>1</sup>H NMR and mass spectral investigations. Title compounds have been tested for their biological potential.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-05-31 17:21:39
 
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http://op.niscair.res.in/index.php/IJC/article/view/63648
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 5 (2022): Indian Journal of Chemistry-(IJC)
 
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