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Malathion alters biochemical parameters of liver in albino rats

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Title Malathion alters biochemical parameters of liver in albino rats
 
Creator Sharma, CD
Bansal, Geeta
 
Subject Cythion
Liver toxicity
Organophosphate pesticides
Pesticide toxicity
 
Description 438-441
Liver represents a key role in the physiology of animals as
most of the metabolic mechanisms occur in it. The pesticides
entered into the human body through various routes viz., oral,
dermal, inhalation, etc. affect the liver and alter the metabolic rate
of the individual. Malathion is an organophosphate pesticide,
commonly used in all kinds of crops to protect them from
different kinds of pests. Here, we studied the toxicological effects
of malathion on the liver of albino rats. Different doses of
malathion @ 25, 50, 75 and 100 mg/ kg body wt. were orally
administered to the rats for 7 and 15 days. The selected
biochemical parameters such as protein, sugar, alkaline
phosphatase, acid phosphatase, glutamyl oxalotransaminase
(GOT), glutamyl pyruvate transaminase (GPT) and glucose-6-
phosphatase dehydrogenase (G6PD) values were measured.
Results indicates that the value of protein, acid phosphatase and
GPT significantly increases as 5.54+0.99 to 7.35+0.48 mg/g, 14.5+2.50
to 27.37+6.43 mol/g/h and 28.52+3.62 to 37.87+3.94 IU/dL,
respectively after treatment. But the sugar, alkaline phosphatase
and G6PD value significantly decreases after treatment from
126.12+2.64 to 84.5+10.83mg/g, 29.12+2.64 to 15.5+4.24,6.46
+1.56 mol/g/h to 4.62+1.18 IU/gHb, respectively. Value of GOT
increased moderately from 38.5+2.44 to44.87+3.31 IU/dL. The
above changes revealed the toxic effects of the pesticide
malathion.
 
Date 2022-06-03T06:35:34Z
2022-06-03T06:35:34Z
2022-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/59841
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(06) [June 2022]