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Investigating The Role Of Platelet Proteins In The Regulation Of Atherosclerosis In Coronary Artery Disease

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Title Investigating The Role Of Platelet Proteins In The
Regulation Of Atherosclerosis In Coronary
Artery Disease
 
Creator Das, Apabrita Ayan
 
Subject Cell Biology & Physiology
 
Description The role of inflammation in all stages of atherosclerotic process is well-known and soluble
TREM like transcript 1 (sTLT1), a platelet protein, is reported to be linked to chronic
inflammation. Yet, no information is available about the involvement of sTLT1 in
atherosclerotic cardiovascular disease. Initially, our results indicated plasma level of sTLT1
was significantly (p800). Quantitative proteomics study on STEMI patients revealed
that 26 proteins were decreased and 38 proteins were increased significantly in STEMI
compared to healthy control. AZGP1, ABCA5, Calicin, PGLYRP2, HAVCR2, C17ORF57
appeared to be relevant to STEMI whereas soluble Galectin-3 seemed relevant to NSTEMI
after cross-validation in human samples. Mechanistic significance in foam cells indicated the
imbalance of RCT through the interaction of AZGP1 with CD36. Additionally, in silico
studies of soluble Galectin-3 with Dectin-1 showed the activation of Dectin-1 mediated
signalling which led to the secretion of pro-inflammatory cytokines. In summary, this study
revealed a unique relationship of some novel proteins apparently responsible for impaired
RCT and chronic inflammation leading to atherothrombosis and myocardial infarction in
CAD.
 
Date 2020
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2836/1/APABRITA_AYAN_DAS__THESIS.pdf
Das, Apabrita Ayan (2020) Investigating The Role Of Platelet Proteins In The Regulation Of Atherosclerosis In Coronary Artery Disease. PhD thesis, University of Calcutta.
 
Relation http://www.eprints.iicb.res.in/2836/