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<strong>Design, synthesis and <em>in vitro </em>antimicrobial activity of fused pyridine-pyrimidine hybrids</strong>

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Title Statement <strong>Design, synthesis and <em>in vitro </em>antimicrobial activity of fused pyridine-pyrimidine hybrids</strong>
 
Added Entry - Uncontrolled Name Desai, Nisheeth C; Maharaja Krishnakumarsinhji Bhavnagar University
Khasiya, Ashvinkumar G; Maharaja Krishnakumarsinhji Bhavnagar University
 
Uncontrolled Index Term Pyridine, pyrimidine, antibacterial activity, antifungal activity
 
Summary, etc. The antimicrobial resistance (AMR) is defined as the rising global concern of infectious illnesses that are resistant to all known antimicrobial agents. The discovery of novel antimicrobial agents is required as microbial resistance increases. Due to this reason, we have synthesized a series of novel pyridine-pyrimidine derivatives (<strong>4a-o</strong>) for the development of antimicrobial agents. The structures of these bioactive molecules were determined using IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectroscopy. The titled compounds were tested for antimicrobial activity against various bacterial and fungal strains using chloramphenicol and griseofulvin as standard drugs. Compounds <strong>4b, 4d </strong>and <strong>4m</strong> exhibited excellent antibacterial activity with MIC = 62.5 µg/mL against <em>E. coli, S. aureus </em>and<em> S. pyogenes </em>respectively. Compounds <strong>4g </strong>and <strong>4o</strong> showed prominent activity against <em>C. albicans</em> with MIC value of 250 µg/mL.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-07-05 16:01:12
 
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http://op.niscair.res.in/index.php/IJC/article/view/59339
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 6 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJC/article/download/59339/465594025
http://op.niscair.res.in/index.php/IJC/article/download/59339/465594036
http://op.niscair.res.in/index.php/IJC/article/download/59339/465594161