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<p>Synthesis, characterization and molecular docking study of novel <em>N-</em>substituted sulfadiazine derivatives as potential anti-mycobacterial agents</p>

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Title Statement <p>Synthesis, characterization and molecular docking study of novel <em>N-</em>substituted sulfadiazine derivatives as potential anti-mycobacterial agents</p>
 
Added Entry - Uncontrolled Name Khan, Ayad Kareem; Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
Razik, Basma M Abd; Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
Ameen, Dina Saleem M; Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
 
Uncontrolled Index Term Synthesis, Characterization, Molecular Docking, Sulfadiazines, Anti-mycobacterial
 
Summary, etc. <p style="text-align: justify;">A new series <em>N-</em>substituted sulfadiazine derivatives attached with different heterocyclic rings such as 4-oxo-1, 4-dihydroquinazolin[7-12], 4-oxo-2<em>H</em>-benzo[1,3]thiazin[13-18] have been synthesized by condensation reactions. The structures of synthesized derivatives are characterized by FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR spectroscopic techniques, and some physicochemical properties. A<strong> </strong>molecular docking study is performed and the binding values show very good matching with experimentally result. The present work deals with newly synthesized sulfadiazine derivatives that are screened for their <em>(In-vitro)</em> antitubercular activity of compounds [7-18] is carried out against Mycobacterium tuberculosis H<sub>37</sub>Rv. compounds [8,11,13,14,15,17] are found most active (MIC=4-16 µg/mL) and compounds [7, 9,10,12,16,18] are found good to moderately active (MIC = 62.5-125 µg/mL) by using isoniazid as standard drug.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-07-05 16:01:12
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/64223
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 6 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en