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<p>Synthesis, characterization and investigation of antimicrobial and antioxidant activities of some new 2-[(4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-one-4-yl)azomethine]phenyl 4-nitrobenzoate derivatives</p>

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Title Statement <p>Synthesis, characterization and investigation of antimicrobial and antioxidant activities of some new 2-[(4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-one-4-yl)azomethine]phenyl 4-nitrobenzoate derivatives</p>
 
Added Entry - Uncontrolled Name Yüksek, H ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Berkyürek, A ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Manap, S ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Özdemir, G ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Beytur, M ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Balseven, H ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Alkan, M ; Education Faculty, Kafkas University, Kars, 36100, Turkey
Aytemiz, F ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
Gürsoy-Kol, Ö ; Department of Chemistry, Kafkas University, Kars, 36100, Turkey
 
Uncontrolled Index Term 1,2,4-Triazol-5-one, Schiff base, Mannich base, acetylation, antioxidant activity, antimicrobial activity
 
Summary, etc. <p style="text-align: justify;">The synthesis of 2-<strong>{</strong>[3-alkyl(aryl)-4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-one-4-yl]azomethine}<strong>-</strong>phenyl 4-nitrobenzoates <strong>3</strong>from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-ones <strong>1</strong> with 2-(4-nitrobenzoxy)-benzaldehyde <strong>2</strong>is described. The acetylation reactions of the compounds <strong>3</strong> giving compounds <strong>4</strong> have been investigated. The compounds <strong>3</strong> have also been treated with 4-piperidinecarboxamide / piperazine in the presence of formaldehyde according to the Mannich reaction to synthesize 2-{[1-(4-piperidinecarboxamide-1-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-one-4-yl]azomethine}-phenyl 4-benzoates <strong>5</strong> and <em>N,N´</em>-bis-{3-alkyl(aryl)-4-[2-(4-nitrobenzoxy)-benzylidenamino]-4,5-dihydro-1<em>H</em>-1,2,4-triazol-5-on-1-yl-methyl}-piperazines <strong>6</strong>. The newly synthesized compounds have been characterized using IR, <sup>1</sup>H and <sup>13</sup>C NMR, UV-Vis and mass spectral data. In addition, the newly synthesized compounds have been screened for their antimicrobial activities. Furthermore, these thirty one new compounds have been analyzed for their <em>in vitro</em> potential antioxidant activities by three different methods.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-07-05 16:01:12
 
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http://op.niscair.res.in/index.php/IJC/article/view/64214
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 6 (2022): Indian Journal of Chemistry-(IJC)
 
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